Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay
CM Embree, R Abu-Alhasan, G Singh - Journal of Biological Chemistry, 2022 - ASBMB
Nonsense-mediated mRNA decay (NMD) is a quality control pathway in eukaryotes that
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced.
The expression of many normal mRNAs that encode full-length polypeptides is also
regulated by this pathway. Such transcript surveillance by NMD is intimately linked to
translation termination. When a ribosome terminates translation at a normal termination
codon, NMD is not activated, and mRNA can undergo repeated rounds of translation. On the …
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced.
The expression of many normal mRNAs that encode full-length polypeptides is also
regulated by this pathway. Such transcript surveillance by NMD is intimately linked to
translation termination. When a ribosome terminates translation at a normal termination
codon, NMD is not activated, and mRNA can undergo repeated rounds of translation. On the …
