TB: the Yin and Yang of lipid mediators
DM Tobin, L Ramakrishnan - Current opinion in pharmacology, 2013 - Elsevier
Highlights•Balanced production of inflammatory mediators is required for protection against
TB.•Genetic variation in lipid mediator expression can determine TB outcomes.•Lipoxin
excess generates hypoinflammatory states that restrict the protective cytokine
TNF.•Excessive pro-inflammatory cues from leukotriene excess are equally host-
detrimental.•Host-directed therapies targeting either state have the potential to restore
inflammatory balance.There is a growing appreciation of the diverse roles that lipid …
TB.•Genetic variation in lipid mediator expression can determine TB outcomes.•Lipoxin
excess generates hypoinflammatory states that restrict the protective cytokine
TNF.•Excessive pro-inflammatory cues from leukotriene excess are equally host-
detrimental.•Host-directed therapies targeting either state have the potential to restore
inflammatory balance.There is a growing appreciation of the diverse roles that lipid …