Transcription termination and the regulation of gene expression

T Platt - Annual review of biochemistry, 1986 - annualreviews.org
T Platt
Annual review of biochemistry, 1986annualreviews.org
The transcriptional apparatus of the cell utilizes both simple and sophisticated mechanisms
to control mRNA biosynthesis, and events related to termination of transcription at the 3'ends
of genes or gene clusters are of major importance. The efficiency of termination, and its
modulation by attenuator sites, anti termination factors, and processing/modification signals,
can have profound effects on gene expression. The vast prokaryotic literature of the past 15
years is covered by numerous reviews (1-5), and parallel developments in eukaryoti. c …
The transcriptional apparatus of the cell utilizes both simple and sophisticated mechanisms to control mRNA biosynthesis, and events related to termination of transcription at the 3'ends of genes or gene clusters are of major importance. The efficiency of termination, and its modulation by attenuator sites, anti termination factors, and processing/modification signals, can have profound effects on gene expression. The vast prokaryotic literature of the past 15 years is covered by numerous reviews (1-5), and parallel developments in eukaryoti. c systems are gaining momentum as well (6-8). From 1981 to the present, over
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