Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress
YB Ouyang, LJ Xu, JF Emery, AS Lee, RG Giffard - Mitochondrion, 2011 - Elsevier
Ca2+ transfer from endoplasmic reticulum (ER) to mitochondria at contact sites between the
organelles can induce mitochondrial dysfunction and programmed cell death after stress.
The ER-localized chaperone glucose-regulated protein 78kDa (GRP78/BiP) protects
neurons against excitotoxicity and apoptosis. Here we show that overexpressing GRP78
protects astrocytes against ischemic injury, reduces net flux of Ca2+ from ER to
mitochondria, increases Ca2+ uptake capacity in isolated mitochondria, reduces free radical …
organelles can induce mitochondrial dysfunction and programmed cell death after stress.
The ER-localized chaperone glucose-regulated protein 78kDa (GRP78/BiP) protects
neurons against excitotoxicity and apoptosis. Here we show that overexpressing GRP78
protects astrocytes against ischemic injury, reduces net flux of Ca2+ from ER to
mitochondria, increases Ca2+ uptake capacity in isolated mitochondria, reduces free radical …