Impairment of PPARα and the fatty acid oxidation pathway aggravates renal fibrosis during aging
KW Chung, EK Lee, MK Lee, GT Oh… - Journal of the …, 2018 - journals.lww.com
Defects in the renal fatty acid oxidation (FAO) pathway have been implicated in the
development of renal fibrosis. Although, compared with young kidneys, aged kidneys show
significantly increased fibrosis with impaired kidney function, the mechanisms underlying the
effects of aging on renal fibrosis have not been investigated. In this study, we investigated
peroxisome proliferator–activated receptor α (PPARα) and the FAO pathway as regulators of
age-associated renal fibrosis. The expression of PPARα and the FAO pathway–associated …
development of renal fibrosis. Although, compared with young kidneys, aged kidneys show
significantly increased fibrosis with impaired kidney function, the mechanisms underlying the
effects of aging on renal fibrosis have not been investigated. In this study, we investigated
peroxisome proliferator–activated receptor α (PPARα) and the FAO pathway as regulators of
age-associated renal fibrosis. The expression of PPARα and the FAO pathway–associated …