Transdermal analysis of glomerular filtration rate (GFR) is an established technique that is
used to assess renal function in mouse and rat models of acute kidney injury and chronic
kidney disease. The measurement system consists of a miniaturized fluorescence detector
that is directly attached to the skin on the back of conscious, freely moving animals, and
measures the excretion kinetics of the exogenous GFR tracer, fluorescein-isothiocyanate
(FITC) conjugated sinistrin (an inulin analog). This system has been described in detail in …