Sirtuin 5 regulates proximal tubule fatty acid oxidation to protect against AKI
T Chiba, KD Peasley, KR Cargill… - Journal of the …, 2019 - journals.lww.com
Background The primary site of damage during AKI, proximal tubular epithelial cells, are
highly metabolically active, relying on fatty acids to meet their energy demands. These cells
are rich in mitochondria and peroxisomes, the two organelles that mediate fatty acid
oxidation. Emerging evidence shows that both fatty acid pathways are regulated by
reversible posttranslational modifications, particularly by lysine acylation. Sirtuin 5 (Sirt5),
which localizes to both mitochondria and peroxisomes, reverses post-translational lysine …
highly metabolically active, relying on fatty acids to meet their energy demands. These cells
are rich in mitochondria and peroxisomes, the two organelles that mediate fatty acid
oxidation. Emerging evidence shows that both fatty acid pathways are regulated by
reversible posttranslational modifications, particularly by lysine acylation. Sirtuin 5 (Sirt5),
which localizes to both mitochondria and peroxisomes, reverses post-translational lysine …