Background Proximal tubular (PT) cells are enriched in mitochondria and peroxisomes.
Whereas mitochondrial fatty acid oxidation (FAO) plays an important role in kidney function
by supporting the high-energy requirements of PT cells, the role of peroxisomal metabolism
remains largely unknown. L-bifunctional protein (EHHADH) catalyzes the second and third
step of peroxisomal FAO. Methods We studied kidneys of WT and Ehhadh KO mice on a
C57BL/6N background using histology, immunohistochemistry, immunofluorescence …