Abstract Carnitine palmitoyltransferase 1 (CPT1) C was the last member of the CPT1 family
of genes to be discovered. CPT1A and CPT1B were identified as the gate-keeper enzymes
for the entry of long-chain fatty acids (as carnitine esters) into mitochondria and their further
oxidation, and they show differences in their kinetics and tissue expression. Although
CPT1C exhibits high sequence similarity to CPT1A and CPT1B, it is specifically expressed
in neurons (a cell-type that does not use fatty acids as fuel to any major extent), it is localized …