[PDF][PDF] SUFU: the Jekyll and Hyde of the cerebellum
Pediatric tumors have enriched the understanding of germline genotype contribution to
tumorigenesis. In this issue of Developmental Cell, Yin et al.(2018) describe genetic models
of Sonic Hedgehog (SHH) subgroup of medulloblastoma with SUFU alterations, painting
more nuanced roles for SUFU in tumorigenesis and maintenance of Gli2 transcription factor
circuitries.
tumorigenesis. In this issue of Developmental Cell, Yin et al.(2018) describe genetic models
of Sonic Hedgehog (SHH) subgroup of medulloblastoma with SUFU alterations, painting
more nuanced roles for SUFU in tumorigenesis and maintenance of Gli2 transcription factor
circuitries.
Pediatric tumors have enriched the understanding of germline genotype contribution to tumorigenesis. In this issue of Developmental Cell, Yin et al. (2018) describe genetic models of Sonic Hedgehog (SHH) subgroup of medulloblastoma with SUFU alterations, painting more nuanced roles for SUFU in tumorigenesis and maintenance of Gli2 transcription factor circuitries.
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