Gender differences in the relationship between leptin, insulin resistance and the autonomic nervous system
DE Flanagan, JC Vaile, GW Petley, DI Phillips… - Regulatory …, 2007 - Elsevier
OBJECTIVES: Leptin, an important hormonal regulator of body weight, has been shown to
stimulate the sympathetic nervous system (SNS) in vitro although the physiological
relevance remains unclear. Increased SNS activity has been implicated in the pathogenesis
of insulin resistance and an increased cardiovascular risk. We have therefore investigated
the relationship between leptin, insulin resistance and cardiac autonomic activity in healthy
young adults. 130 healthy men and women age 20.9 years were studied. Insulin sensitivity …
stimulate the sympathetic nervous system (SNS) in vitro although the physiological
relevance remains unclear. Increased SNS activity has been implicated in the pathogenesis
of insulin resistance and an increased cardiovascular risk. We have therefore investigated
the relationship between leptin, insulin resistance and cardiac autonomic activity in healthy
young adults. 130 healthy men and women age 20.9 years were studied. Insulin sensitivity …