Effect of verapamil on pancreatic beta cell function in newly diagnosed pediatric type 1 diabetes: a randomized clinical trial
GP Forlenza, J McVean, RW Beck, C Bauza, R Bailey… - Jama, 2023 - jamanetwork.com
Importance In preclinical studies, thioredoxin-interacting protein overexpression induces
pancreatic beta cell apoptosis and is involved in glucotoxicity-induced beta cell death.
Calcium channel blockers reduce these effects and may be beneficial to beta cell
preservation in type 1 diabetes. Objective To determine the effect of verapamil on pancreatic
beta cell function in children and adolescents with newly diagnosed type 1 diabetes. Design,
Setting, and Participants This double-blind, randomized clinical trial including children and …
pancreatic beta cell apoptosis and is involved in glucotoxicity-induced beta cell death.
Calcium channel blockers reduce these effects and may be beneficial to beta cell
preservation in type 1 diabetes. Objective To determine the effect of verapamil on pancreatic
beta cell function in children and adolescents with newly diagnosed type 1 diabetes. Design,
Setting, and Participants This double-blind, randomized clinical trial including children and …