The role of estrogens in pancreatic islet physiopathology
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity, 2017•Springer
In rodent models of insulin-deficient diabetes, 17β-estradiol (E2) protects pancreatic insulin-
producing β-cells against oxidative stress, amyloid polypeptide toxicity, gluco-lipotoxicity,
and apoptosis. Three estrogen receptors (ERs)—ERα, ERβ, and the G protein-coupled ER
(GPER)—have been identified in rodent and human β-cells. This chapter describes recent
advances in our understanding of the role of ERs in islet β-cell function, nutrient
homeostasis, survival from pro-apoptotic stimuli, and proliferation. We discuss why and how …
producing β-cells against oxidative stress, amyloid polypeptide toxicity, gluco-lipotoxicity,
and apoptosis. Three estrogen receptors (ERs)—ERα, ERβ, and the G protein-coupled ER
(GPER)—have been identified in rodent and human β-cells. This chapter describes recent
advances in our understanding of the role of ERs in islet β-cell function, nutrient
homeostasis, survival from pro-apoptotic stimuli, and proliferation. We discuss why and how …
Abstract
In rodent models of insulin-deficient diabetes, 17β-estradiol (E2) protects pancreatic insulin-producing β-cells against oxidative stress, amyloid polypeptide toxicity, gluco-lipotoxicity, and apoptosis. Three estrogen receptors (ERs)—ERα, ERβ, and the G protein-coupled ER (GPER)—have been identified in rodent and human β-cells. This chapter describes recent advances in our understanding of the role of ERs in islet β-cell function, nutrient homeostasis, survival from pro-apoptotic stimuli, and proliferation. We discuss why and how ERs represent potential therapeutic targets for the maintenance of functional β-cell mass.
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