Role of α3β1 and α2β1 integrins in melanoma cell migration
IG Yoshinaga, J Vink, SK Dekker, MC Mihm Jr… - Melanoma …, 1993 - journals.lww.com
Recent findings Indicate that variable expression of [beta] Integrins may play a role In
differential melanoma cell motility. Primary melanoma (PM) and metastatic melanoma (MM)
cultures, derived from the same patient, were tested for their [beta] 1,[alpha] 2,[alpha] 3, and
[alpha] 6, Integrln subunlt expression and cell migration on type IV collagen (CN IV) or
lamlnln (LN). The MM cell line expressed markedly Increased levels of the [beta] 1,[alpha] 2
and [alpha] 3, but not [alpha] 6 subunlt compared to the PM cell line. The MM cell migration …
differential melanoma cell motility. Primary melanoma (PM) and metastatic melanoma (MM)
cultures, derived from the same patient, were tested for their [beta] 1,[alpha] 2,[alpha] 3, and
[alpha] 6, Integrln subunlt expression and cell migration on type IV collagen (CN IV) or
lamlnln (LN). The MM cell line expressed markedly Increased levels of the [beta] 1,[alpha] 2
and [alpha] 3, but not [alpha] 6 subunlt compared to the PM cell line. The MM cell migration …