Sulfenic acid modification of endothelin B receptor is responsible for the benefit of a nonsteroidal mineralocorticoid receptor antagonist in renal ischemia
J Barrera-Chimal, S Prince, F Fadel… - Journal of the …, 2016 - journals.lww.com
AKI is associated with high mortality rates and the development of CKD.
Ischemia/reperfusion (IR) is an important cause of AKI. Unfortunately, there is no available
pharmacologic approach to prevent or limit renal IR injury in common clinical practice. Renal
IR is characterized by diminished nitric oxide bioavailability and reduced renal blood flow;
however, the mechanisms leading to these alterations are poorly understood. In a rat model
of renal IR, we investigated whether the administration of the novel nonsteroidal …
Ischemia/reperfusion (IR) is an important cause of AKI. Unfortunately, there is no available
pharmacologic approach to prevent or limit renal IR injury in common clinical practice. Renal
IR is characterized by diminished nitric oxide bioavailability and reduced renal blood flow;
however, the mechanisms leading to these alterations are poorly understood. In a rat model
of renal IR, we investigated whether the administration of the novel nonsteroidal …