Physiology and pathophysiology of the intrarenal renin-angiotensin system: an update
T Yang, C Xu - Journal of the American Society of Nephrology, 2017 - journals.lww.com
The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular
volume homeostasis and blood pressure through complex mechanisms. Apart from the well
known systemic RAS, occurrence of a local RAS has been documented in multiple tissues,
including the kidney. A large body of recent evidence from pharmacologic and genetic
studies, particularly those using various transgenic approaches to manipulate intrarenal
levels of RAS components, has established the important role of intrarenal RAS in …
volume homeostasis and blood pressure through complex mechanisms. Apart from the well
known systemic RAS, occurrence of a local RAS has been documented in multiple tissues,
including the kidney. A large body of recent evidence from pharmacologic and genetic
studies, particularly those using various transgenic approaches to manipulate intrarenal
levels of RAS components, has established the important role of intrarenal RAS in …