Maintaining blood glucose concentration within a relatively narrow range through periods of
fasting or excess nutrient availability is essential to the survival of the organism. This is
achieved through an intricate balance between glucose uptake and endogenous glucose
production to maintain constant glucose concentrations. The liver plays a major role in
maintaining normal whole body glucose levels by regulating the processes of de novo
glucose production (gluconeogenesis) and glycogen breakdown (glycogenolysis), thus …