Prorenin and angiotensin-dependent renal vasoconstriction in type 1 and type 2 diabetes
AR Stankovic, NDL Fisher… - Journal of the American …, 2006 - journals.lww.com
Prorenin is a powerful marker for risk of nephropathy and retinopathy in diabetes, but the
responsible mechanism remains unclear. Studied were 35 patients with diabetes (18 with
type 1 and 17 with type 2) and 69 age-matched healthy subjects with para-aminohippurate
and inulin clearances and their response to captopril. All patients with diabetes had normal
renal function and no microalbuminuria. Prorenin was calculated as the difference between
total renin and active renin. Active renin level in patients with diabetes (11.6±0.9 μU/ml) was …
responsible mechanism remains unclear. Studied were 35 patients with diabetes (18 with
type 1 and 17 with type 2) and 69 age-matched healthy subjects with para-aminohippurate
and inulin clearances and their response to captopril. All patients with diabetes had normal
renal function and no microalbuminuria. Prorenin was calculated as the difference between
total renin and active renin. Active renin level in patients with diabetes (11.6±0.9 μU/ml) was …