Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation
JM Metzger, MV Westfall - Circulation research, 2004 - Am Heart Assoc
JM Metzger, MV Westfall
Circulation research, 2004•Am Heart AssocTroponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric
molecular switch, directly regulating the contractile event in concert with intracellular calcium
signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and
posttranslational modifications are known to directly affect sarcomeric regulation. This
review focuses on physiologically relevant covalent and noncovalent modifications in
troponin as part of a thematic series on cardiac thin filament function in health and disease.
molecular switch, directly regulating the contractile event in concert with intracellular calcium
signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and
posttranslational modifications are known to directly affect sarcomeric regulation. This
review focuses on physiologically relevant covalent and noncovalent modifications in
troponin as part of a thematic series on cardiac thin filament function in health and disease.
Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and posttranslational modifications are known to directly affect sarcomeric regulation. This review focuses on physiologically relevant covalent and noncovalent modifications in troponin as part of a thematic series on cardiac thin filament function in health and disease.
Am Heart Assoc