Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco (endo) plasmic reticulum stress and apoptosis
XH Liu, ZY Zhang, KB Andersson, C Husberg… - Cell calcium, 2011 - Elsevier
Reduced sarco (endo) plasmic reticulum (SR) Ca2+ ATPase (SERCA2) contributes to the
impaired cardiomyocyte Ca2+ homeostasis observed in heart failure. We hypothesized that
a reduction in SERCA2 also elicits myocardial ER/SR stress responses, including unfolded
protein responses (UPR) and cardiomyocyte apoptosis, which may additionally contribute to
the pathophysiology of this condition. Left ventricular myocardium from mice with
cardiomyocyte-specific tamoxifen-inducible disruption of Serca2 (SERCA2 KO) was …
impaired cardiomyocyte Ca2+ homeostasis observed in heart failure. We hypothesized that
a reduction in SERCA2 also elicits myocardial ER/SR stress responses, including unfolded
protein responses (UPR) and cardiomyocyte apoptosis, which may additionally contribute to
the pathophysiology of this condition. Left ventricular myocardium from mice with
cardiomyocyte-specific tamoxifen-inducible disruption of Serca2 (SERCA2 KO) was …