Mice carrying a conditional Serca2flox allele for the generation of Ca2+ handling-deficient mouse models
KB Andersson, AV Finsen, C Sjåland, LH Winer… - Cell Calcium, 2009 - Elsevier
Sarco (endo) plasmic reticulum calcium ATPases (SERCA) are cellular pumps that transport
Ca2+ into the sarcoplasmic reticulum (SR). Serca2 is the most widely expressed gene family
member. The very early embryonic lethality of Serca2null mouse embryos has precluded
further evaluation of loss of Serca2 function in the context of organ physiology. We have
generated mice carrying a conditional Serca2flox allele which allows disruption of the
Serca2 gene in an organ-specific and/or inducible manner. The model was tested by mating …
Ca2+ into the sarcoplasmic reticulum (SR). Serca2 is the most widely expressed gene family
member. The very early embryonic lethality of Serca2null mouse embryos has precluded
further evaluation of loss of Serca2 function in the context of organ physiology. We have
generated mice carrying a conditional Serca2flox allele which allows disruption of the
Serca2 gene in an organ-specific and/or inducible manner. The model was tested by mating …