Molecular cytogenetics of pediatric adipocytic tumors
B Dadone, S Refae, C Lemarié-Delaunay, L Bianchini… - Cancer genetics, 2015 - Elsevier
Both epidemiologic and cytogenetic data on pediatric adipose tissue tumors are scarce.
Pediatric adipose tumors are mainly represented by lipomas, though only 28 cytogenetic
descriptions of pediatric lipoma have been reported to date. Similar to adult cases, most of
these pediatric lipomas harbored rearrangements of the chromosomal regions 12q14–q15
and 6p21, involving the HMGA2 and HMGA1 genes. Further cytogenetic studies of pediatric
lipoma would be useful to determinate whether some partner genes of HMGA2, such as …
Pediatric adipose tumors are mainly represented by lipomas, though only 28 cytogenetic
descriptions of pediatric lipoma have been reported to date. Similar to adult cases, most of
these pediatric lipomas harbored rearrangements of the chromosomal regions 12q14–q15
and 6p21, involving the HMGA2 and HMGA1 genes. Further cytogenetic studies of pediatric
lipoma would be useful to determinate whether some partner genes of HMGA2, such as …