Purpose Fetal growth is a complex process involving maternal, placental and fetal factors.
The etiology of fetal growth retardation remains unknown in many cases. The aim of this
study is to identify novel human mutations and genes related to Silver–Russell syndrome
(SRS), a syndromic form of fetal growth retardation, usually caused by epigenetic
downregulation of the potent fetal growth factor IGF2. Methods Whole-exome sequencing
was carried out on members of an SRS familial case. The candidate gene from the familial …