[HTML][HTML] Heterogeneity and Differentiation Trajectories of Infiltrating CD8+ T Cells in Lung Adenocarcinoma
X Song, G Zhao, G Wang, H Gao - Cancers, 2022 - mdpi.com
Simple Summary CD8+ T cells infiltrating the tumor microenvironment (TME) of lung
adenocarcinoma (LUAD) play a crucial role in establishing anti-tumor immunotherapy. The
number of CD8+ T cells affects the treatment response, but their functional status plays a
more critical role, and this global landscape is still unclear. We divided CD8+ T cells into ten
subsets by analyzing a LUAD single-cell dataset. The dynamic process of cell differentiation
and functional exhaustion of CD8+ T cells was further discussed, and potential biomarkers …
adenocarcinoma (LUAD) play a crucial role in establishing anti-tumor immunotherapy. The
number of CD8+ T cells affects the treatment response, but their functional status plays a
more critical role, and this global landscape is still unclear. We divided CD8+ T cells into ten
subsets by analyzing a LUAD single-cell dataset. The dynamic process of cell differentiation
and functional exhaustion of CD8+ T cells was further discussed, and potential biomarkers …
[CITATION][C] Heterogeneity and Differentiation Trajectories of Infiltrating CD8+ T Cells in Lung Adenocarcinoma. Cancers 2022, 14, 5183
X Song, G Zhao, G Wang, H Gao - 2022 - europepmc.org
CD8+ T cells infiltrating the tumor microenvironment (TME) of lung adenocarcinoma (LUAD)
are critical for establishing antitumor immunity. Nevertheless, the global landscape of their
numbers, functional status, and differentiation trajectories remains unclear. In the single-cell
RNA-sequencing (scRNA-seq) dataset GSE131907 of LUAD, the CD8+ T cells were
selected for TSNE clustering, and the results showed that they could be divided into ten
subsets. The cell differentiation trajectory showed the presence of abundant transition-state …
are critical for establishing antitumor immunity. Nevertheless, the global landscape of their
numbers, functional status, and differentiation trajectories remains unclear. In the single-cell
RNA-sequencing (scRNA-seq) dataset GSE131907 of LUAD, the CD8+ T cells were
selected for TSNE clustering, and the results showed that they could be divided into ten
subsets. The cell differentiation trajectory showed the presence of abundant transition-state …