[HTML][HTML] Control of IBMIR in neonatal porcine islet xenotransplantation in baboons
WJ Hawthorne, EJ Salvaris, P Phillips, J Hawkes… - American Journal of …, 2014 - Elsevier
The instant blood-mediated inflammatory reaction (IBMIR) is a major obstacle to the
engraftment of intraportal pig islet xenografts in primates. Higher expression of the galactose-
α1, 3-galactose (αGal) xenoantigen on neonatal islet cell clusters (NICC) than on adult pig
islets may provoke a stronger reaction, but this has not been tested in the baboon model.
Here, we report that WT pig NICC xenografts triggered profound IBMIR in baboons, with
intravascular clotting and graft destruction occurring within hours, which was not prevented …
engraftment of intraportal pig islet xenografts in primates. Higher expression of the galactose-
α1, 3-galactose (αGal) xenoantigen on neonatal islet cell clusters (NICC) than on adult pig
islets may provoke a stronger reaction, but this has not been tested in the baboon model.
Here, we report that WT pig NICC xenografts triggered profound IBMIR in baboons, with
intravascular clotting and graft destruction occurring within hours, which was not prevented …