Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors
S Zhang, G Rao, A Heimberger, S Li - Cytokine & growth factor reviews, 2023 - Elsevier
Brain tumors are among the 10 leading causes of cancer-related death and present unique
treatment challenges due to their critical location, genetic heterogeneity, and the blood-brain
barrier. Recent advances in targeted immunotherapy and immune checkpoint blocking
therapy provide alternative therapeutic strategies for brain tumors. Fibrinogen-like protein 2
(FGL2), which induces transformation from low-grade glioma to high-grade glioblastoma, is
a type II membrane protein that is highly expressed in both host immune cells and tumor …
treatment challenges due to their critical location, genetic heterogeneity, and the blood-brain
barrier. Recent advances in targeted immunotherapy and immune checkpoint blocking
therapy provide alternative therapeutic strategies for brain tumors. Fibrinogen-like protein 2
(FGL2), which induces transformation from low-grade glioma to high-grade glioblastoma, is
a type II membrane protein that is highly expressed in both host immune cells and tumor …