[HTML][HTML] Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance
Foxp3+ regulatory T cells (Tregs) have an essential role in immune and allograft tolerance.
However, in both kidney and liver transplantation in humans, FOXP3+ Tregs have been
associated with clinical rejection. Therefore, the role and function of graft infiltrating Tregs
have been of great interest. In the studies outlined, we demonstrated that Foxp3+ Tregs
were expanded in tolerant kidney allografts and in draining lymph nodes in the DBA/2 (H-2
d) to C57BL/6 (H-2 b) mouse spontaneous kidney allograft tolerance model. Kidney allograft …
However, in both kidney and liver transplantation in humans, FOXP3+ Tregs have been
associated with clinical rejection. Therefore, the role and function of graft infiltrating Tregs
have been of great interest. In the studies outlined, we demonstrated that Foxp3+ Tregs
were expanded in tolerant kidney allografts and in draining lymph nodes in the DBA/2 (H-2
d) to C57BL/6 (H-2 b) mouse spontaneous kidney allograft tolerance model. Kidney allograft …