[HTML][HTML] Chimeric receptors composed of phosphoinositide 3-kinase domains and Fcγ receptor ligand-binding domains mediate phagocytosis in COS fibroblasts
MB Lowry, AM Duchemin, KM Coggeshall… - Journal of Biological …, 1998 - ASBMB
Receptors for the Fc portion of IgG (FcγR) initiate phagocytosis of IgG-opsonized particles by
a process involving the assembly of a multi-molecular signaling complex. Several members
of this complex have been identified, including Src family kinases, Syk/ZAP 70 family
kinases, and phosphoinositide 3-kinase (PI3-K). To test directly the role of PI3-K in
mediating phagocytosis, we assessed the phagocytic ability of chimeric receptors composed
of FcγR extracellular and transmembrane domains fused to regions of the p85 subunit of PI3 …
a process involving the assembly of a multi-molecular signaling complex. Several members
of this complex have been identified, including Src family kinases, Syk/ZAP 70 family
kinases, and phosphoinositide 3-kinase (PI3-K). To test directly the role of PI3-K in
mediating phagocytosis, we assessed the phagocytic ability of chimeric receptors composed
of FcγR extracellular and transmembrane domains fused to regions of the p85 subunit of PI3 …