In rats, esophagogastroduodenal anastomosis (EGDA) without concomitant chemical
carcinogen treatment can lead to columnar-lined esophagus (CLE) including metaplasia,
dysplasia, and esophageal adenocarcinoma (EAC). This study describes the morphology
and phenotypic features of CLE and EAC in the rat model and compares them with the
corresponding lesions in human Barrett's esophagus (BE). Swiss roll preparations of
esophagi of EGDA rats and biopsies from human BE containing specialized intestinal …