Maintenance proton pump inhibition therapy and risk of oesophageal cancer
N Brusselaers, L Engstrand, J Lagergren - Cancer epidemiology, 2018 - Elsevier
Background The association of long-term use of proton pump inhibitors (PPIs) with
oesophageal adenocarcinoma has been poorly defined. Our aim was to assess the risk of
oesophageal cancer assessing confounding by indication. Methods This population-based
cohort study included all 796,492 adults exposed to maintenance therapy with PPIs in
Sweden in 2005–2012. Standardised incidence ratios (SIRs) and 95% confidence intervals
(CIs) were calculated to assess the risk of oesophageal adenocarcinoma (and squamous …
oesophageal adenocarcinoma has been poorly defined. Our aim was to assess the risk of
oesophageal cancer assessing confounding by indication. Methods This population-based
cohort study included all 796,492 adults exposed to maintenance therapy with PPIs in
Sweden in 2005–2012. Standardised incidence ratios (SIRs) and 95% confidence intervals
(CIs) were calculated to assess the risk of oesophageal adenocarcinoma (and squamous …