Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model
Z Zheng, X Xu, X Zhang, A Wang, C Zhang… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Air pollution is a global challenge to public health. Epidemiological
studies have linked exposure to ambient particulate matter with aerodynamic diameters< 2.5
μm (PM2. 5) to the development of metabolic diseases. In this study, we investigated the
effect of PM2. 5 exposure on liver pathogenesis and the mechanism by which ambient PM2.
5 modulates hepatic pathways and glucose homeostasis. METHODS: Using “Ohio's Air
Pollution Exposure System for the Interrogation of Systemic Effects (OASIS)-1”, we …
studies have linked exposure to ambient particulate matter with aerodynamic diameters< 2.5
μm (PM2. 5) to the development of metabolic diseases. In this study, we investigated the
effect of PM2. 5 exposure on liver pathogenesis and the mechanism by which ambient PM2.
5 modulates hepatic pathways and glucose homeostasis. METHODS: Using “Ohio's Air
Pollution Exposure System for the Interrogation of Systemic Effects (OASIS)-1”, we …