The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding
of linear polypeptides and proteins, a process tightly governed by the ER‐resident enzymes
and chaperones. Failure to shape the proper 3‐dimensional architecture of proteins
culminates in the accumulation of misfolded or unfolded proteins within the ER, disturbs ER
homeostasis, and leads to canonically defined ER stress. Recent studies have elucidated
that cellular perturbations, such as lipotoxicity, can also lead to ER stress. In response to ER …