[HTML][HTML] Metabolism of 4β-hydroxycholesterol in humans
K Bodin, U Andersson, E Rystedt, E Ellis… - Journal of Biological …, 2002 - ASBMB
One of the major oxysterols in the human circulation is 4β-hydroxycholesterol formed from
cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4. Deuterium-labeled 4β-
hydroxycholesterol was injected into two healthy volunteers, and the apparent half-life was
found to be 64 and 60 h, respectively. We have determined earlier the half-lives for 7α-, 27-,
and 24-hydroxycholesterol to be∼ 0.5, 0.75, and 14 h, respectively. Patients treated with
certain antiepileptic drugs have up to 20-fold increased plasma concentrations of 4β …
cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4. Deuterium-labeled 4β-
hydroxycholesterol was injected into two healthy volunteers, and the apparent half-life was
found to be 64 and 60 h, respectively. We have determined earlier the half-lives for 7α-, 27-,
and 24-hydroxycholesterol to be∼ 0.5, 0.75, and 14 h, respectively. Patients treated with
certain antiepileptic drugs have up to 20-fold increased plasma concentrations of 4β …