Increased frequencies of basophils, type 2 innate lymphoid cells and Th2 cells in skin of patients with atopic dermatitis but not psoriasis
S Mashiko, H Mehta, R Bissonnette, M Sarfati - Journal of dermatological …, 2017 - Elsevier
Background Pathogenesis of atopic dermatitis (AD) involves interaction between type 2 cells
that include basophils, mast cells, innate lymphoid type 2 cells (ILC2), and Th2 cells. Levels
of IL-4 and IL-13 are elevated in AD patients. Objective Here, we investigated the distribution
of type 2 cells and the source of IL-4 and IL-13 in skin and blood of AD relative to psoriasis.
Methods Lesional skin biopsies and blood were collected from patients. Skin cell
suspensions were prepared by mild enzymatic digestion and mechanical dissociation. IL-4 …
that include basophils, mast cells, innate lymphoid type 2 cells (ILC2), and Th2 cells. Levels
of IL-4 and IL-13 are elevated in AD patients. Objective Here, we investigated the distribution
of type 2 cells and the source of IL-4 and IL-13 in skin and blood of AD relative to psoriasis.
Methods Lesional skin biopsies and blood were collected from patients. Skin cell
suspensions were prepared by mild enzymatic digestion and mechanical dissociation. IL-4 …