Steroids have a wide spectrum of impact, serving as fundamental regulators of nearly every
physiological process within the human body. Therapeutic applications of steroids are
equally broad, with a diverse range of medications and targets. Within the central nervous
system (CNS), steroids influence development, memory, behavior, and disease outcomes.
Moreover, steroids are well recognized as to their impact on the vascular endothelium. The
blood–brain barrier (BBB) at the level of the brain microvascular endothelium serves as the …