Chloroquine attenuates hemorrhagic shock—induced immunosuppression and decreases susceptibility to sepsis
W Ertel, MH Morrison, A Ayala, IH Chaudry - Archives of Surgery, 1992 - jamanetwork.com
• Hemorrhagic shock causes a severe suppression of cellular immunity and an increased
susceptibility to sepsis that may be due to increased release of prostaglandin E 2 by
macrophages. Since chloroquine inhibits the secretion of prostaglandin E 2 by
macrophages in vitro, the effects of chloroquine administration in vivo following hemorrhagic
shock on macrophage prostaglandin E 2 secretion and on depressed cellular immunity were
examined. Inbred C3H/HeN male mice, aged 6 to 8 weeks, were bled to a mean blood …
susceptibility to sepsis that may be due to increased release of prostaglandin E 2 by
macrophages. Since chloroquine inhibits the secretion of prostaglandin E 2 by
macrophages in vitro, the effects of chloroquine administration in vivo following hemorrhagic
shock on macrophage prostaglandin E 2 secretion and on depressed cellular immunity were
examined. Inbred C3H/HeN male mice, aged 6 to 8 weeks, were bled to a mean blood …