[HTML][HTML] Lipoteichoic acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide …
NWJ Schröder, S Morath, C Alexander… - Journal of biological …, 2003 - ASBMB
Lipoteichoic acid (LTA) derived fromStreptococcus pneumoniae, purified employing a
chloroform/methanol protocol, and from Staphylococcus aureus, prepared by the recently
described butanol extraction procedure, was investigated regarding its interaction with
lipopolysaccharide (LPS)-binding protein (LBP), CD14, Toll-like receptors (TLRs)-2 and-4,
and MD-2. LTA from both organisms induced cytokine synthesis in human mononuclear
phagocytes. Activation was LBP-and CD14-dependent, and formation of complexes of LTA …
chloroform/methanol protocol, and from Staphylococcus aureus, prepared by the recently
described butanol extraction procedure, was investigated regarding its interaction with
lipopolysaccharide (LPS)-binding protein (LBP), CD14, Toll-like receptors (TLRs)-2 and-4,
and MD-2. LTA from both organisms induced cytokine synthesis in human mononuclear
phagocytes. Activation was LBP-and CD14-dependent, and formation of complexes of LTA …