[HTML][HTML] Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism
MB Nilsson, G Armaiz-Pena, R Takahashi… - Journal of Biological …, 2007 - ASBMB
Recent studies have demonstrated that chronic stress promotes tumor growth,
angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine,
interleukin 6 (IL-6), are known to be elevated in individuals experiencing chronic stress, but
the mechanism (s) by which this cytokine is regulated and its role in tumor growth remain
under investigation. Here we show that stress hormones such as norepinephrine lead to
increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells …
angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine,
interleukin 6 (IL-6), are known to be elevated in individuals experiencing chronic stress, but
the mechanism (s) by which this cytokine is regulated and its role in tumor growth remain
under investigation. Here we show that stress hormones such as norepinephrine lead to
increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells …
