[HTML][HTML] Activity-induced changes in skeletal muscle metabolism measured with optical spectroscopy
TE Ryan, WM Southern, JT Brizendine… - Medicine and science …, 2013 - ncbi.nlm.nih.gov
Medicine and science in sports and exercise, 2013•ncbi.nlm.nih.gov
Purpose Previous studies have used near-infrared spectroscopy (NIRS) to measure skeletal
muscle mitochondrial capacity. This study tested the hypothesis that NIRS measured
mitochondrial capacity would improve with endurance exercise training and decline with
detraining. Methods Nine, young, participants performed four weeks of progressively
increasing endurance exercise training of the wrist flexor muscles followed by approximately
five weeks of inactivity. The rate of recovery of muscle oxygen consumption (mVO 2) was …
muscle mitochondrial capacity. This study tested the hypothesis that NIRS measured
mitochondrial capacity would improve with endurance exercise training and decline with
detraining. Methods Nine, young, participants performed four weeks of progressively
increasing endurance exercise training of the wrist flexor muscles followed by approximately
five weeks of inactivity. The rate of recovery of muscle oxygen consumption (mVO 2) was …
Abstract
Purpose
Previous studies have used near-infrared spectroscopy (NIRS) to measure skeletal muscle mitochondrial capacity. This study tested the hypothesis that NIRS measured mitochondrial capacity would improve with endurance exercise training and decline with detraining.
Methods
Nine, young, participants performed four weeks of progressively increasing endurance exercise training of the wrist flexor muscles followed by approximately five weeks of inactivity. The rate of recovery of muscle oxygen consumption (mVO 2) was measured with NIRS every 3-7 days, indicating mitochondrial oxidative capacity.
Results
A linear increase in mitochondrial capacity (NIRS rate constant) was found with a group average of 64±37% improvement after four weeks of exercise training (p< 0.05). Mitochondrial capacity declined exponentially upon cessation of exercise training, with a mean half-time of~ 7.7 days.
Conclusion
Both the magnitude and time course of mitochondrial adaptations to exercise training and detraining measured with NIRS was consistent with previous studies using both in vitro and in vivo techniques. These findings show that NIRS based measurements can detect meaningful changes in mitochondrial capacity.
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