Cell culture studies on neurofibromatosis (von Recklinghausen). II. Occurrence of glial cells in primary cultures of peripheral neurofibromas
W Krone, G Jirikowski, O Mühleck, H Kling, H Gall - Human genetics, 1983 - Springer
W Krone, G Jirikowski, O Mühleck, H Kling, H Gall
Human genetics, 1983•SpringerThe occurrence of glial cells in primary cultures established from peripheral neurofibromas
of 18 patients with neurofibromatosis (von Recklinghausen) is described. The spindle-
shaped cells can be distinguished from fibroblasts on the basis of morphological and
ultrastructural criteria. As demonstrated by immunocytochemical analysis, the spindle cells
express S-100 protein. Neither glial fibrillar acidic protein nor myelin basic protein can be
detected in these cells. In many respects the spindle cells resemble immature Schwann cells …
of 18 patients with neurofibromatosis (von Recklinghausen) is described. The spindle-
shaped cells can be distinguished from fibroblasts on the basis of morphological and
ultrastructural criteria. As demonstrated by immunocytochemical analysis, the spindle cells
express S-100 protein. Neither glial fibrillar acidic protein nor myelin basic protein can be
detected in these cells. In many respects the spindle cells resemble immature Schwann cells …
Summary
The occurrence of glial cells in primary cultures established from peripheral neurofibromas of 18 patients with neurofibromatosis (von Recklinghausen) is described. The spindle-shaped cells can be distinguished from fibroblasts on the basis of morphological and ultrastructural criteria. As demonstrated by immunocytochemical analysis, the spindle cells express S-100 protein. Neither glial fibrillar acidic protein nor myelin basic protein can be detected in these cells. In many respects the spindle cells resemble immature Schwann cells in culture.
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