Inhibition of Sphingosine Kinase 1 Attenuates Sepsis-induced Microvascular Leakage via Inhibiting Macrophage NLRP3 Inflammasome Activation in Mice
M Zhong, W Wu, Y Wang, H Mao, J Song, S Chen… - …, 2020 - pubs.asahq.org
Background Sepsis is the overwhelming inflammatory response to infection, in which
nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3)
inflammasome plays a crucial role. Shingosine-1-phosphate is reported to evoke NLRP3
inflammasome activation. Sphingosine kinase 1 (SphK1) is the major kinase that catalyzes
bioactive lipid shingosine-1–phosphate formation and its role in sepsis remains uncertain.
The authors hypothesize that SphK1 elicits NLRP3 inflammasome activation and …
nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3)
inflammasome plays a crucial role. Shingosine-1-phosphate is reported to evoke NLRP3
inflammasome activation. Sphingosine kinase 1 (SphK1) is the major kinase that catalyzes
bioactive lipid shingosine-1–phosphate formation and its role in sepsis remains uncertain.
The authors hypothesize that SphK1 elicits NLRP3 inflammasome activation and …
