Macrophage phagocytosis of myelin in vitro determined by flow cytometry: phagocytosis is mediated by CR3 and induces production of tumor necrosis factor-α and …
LJW van der Laan, SR Ruuls, KS Weber… - Journal of …, 1996 - Elsevier
Demyelination of axons in the central nervous system (CNS) during multiple sclerosis (MS)
and its animal model experimental allergic encephalomyelitis (EAE) is a result of
phagocytosis and digestion by macrophages (M ϕ) and the local release of inflammatory
mediators like tumor necrosis factor-α (TNF-α) and nitric oxide (NO). We have investigated
the process of myelin phagocytosis by M ϕ in vitro using flow cytometric analysis. The
binding and uptake of CNS-derived myelin was dose dependent, was abolished in the …
and its animal model experimental allergic encephalomyelitis (EAE) is a result of
phagocytosis and digestion by macrophages (M ϕ) and the local release of inflammatory
mediators like tumor necrosis factor-α (TNF-α) and nitric oxide (NO). We have investigated
the process of myelin phagocytosis by M ϕ in vitro using flow cytometric analysis. The
binding and uptake of CNS-derived myelin was dose dependent, was abolished in the …