[HTML][HTML] Inhibition of MyD88 signaling skews microglia/macrophage polarization and attenuates neuronal apoptosis in the hippocampus after status epilepticus in mice
JT Liu, SX Wu, H Zhang, F Kuang - Neurotherapeutics, 2018 - Elsevier
Inflammation is implicated in epileptogenesis. Activated microglia and macrophages
(MG/MΦ) are found in the brains of patients with epilepsy-related diseases and animal
models of epilepsy. It is not yet known how the MG/MΦ activation phenotype affects
pathological changes in the brain after a single seizure. In this study, we had 2 main
purposes: first, to characterize post-status epilepticus (SE) inflammation by tracking MG/MΦ
polarization, and, second, to explore the role of an innate immune receptor adaptor protein …
(MG/MΦ) are found in the brains of patients with epilepsy-related diseases and animal
models of epilepsy. It is not yet known how the MG/MΦ activation phenotype affects
pathological changes in the brain after a single seizure. In this study, we had 2 main
purposes: first, to characterize post-status epilepticus (SE) inflammation by tracking MG/MΦ
polarization, and, second, to explore the role of an innate immune receptor adaptor protein …