Reactive oxygen species in status epilepticus
T Shekh-Ahmad, S Kovac, AY Abramov, MC Walker - Epilepsy & behavior, 2019 - Elsevier
There has been growing evidence for a critical role of oxidative stress in neurodegenerative
disease, providing novel targets for disease modifying treatments. Although antioxidants
have been suggested and tried in the treatment of epilepsy, it is only recently that the pivotal
role of oxidative stress in the pathophysiology of status epilepticus has been recognized.
Although conventionally thought to be generated by mitochondria, reactive oxygen species
during status epilepticus and prolonged seizure are generated mainly by NADPH …
disease, providing novel targets for disease modifying treatments. Although antioxidants
have been suggested and tried in the treatment of epilepsy, it is only recently that the pivotal
role of oxidative stress in the pathophysiology of status epilepticus has been recognized.
Although conventionally thought to be generated by mitochondria, reactive oxygen species
during status epilepticus and prolonged seizure are generated mainly by NADPH …