Microglia are brain-resident immune cells that contribute to the maintenance of brain
homeostasis. In the epileptic brain, microglia show various activation phenotypes depending
on the stage of epileptogenesis. Therefore, it remains unclear whether microglial activation
acts in a pro-epileptic or anti-epileptic manner. In mesial temporal lobe epilepsy, one of the
most common form of epilepsies, microglia exhibit at least two distinct morphologies,
amoeboid shape and ramified shape. Amoeboid microglia are often found in sclerotic area …