[HTML][HTML] Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
H Takeuchi, S Jin, J Wang, G Zhang… - Journal of Biological …, 2006 - ASBMB
Glutamate released by activated microglia induces excitoneurotoxicity and may contribute to
neuronal damage in neurodegenerative diseases, including Alzheimer disease, Parkinson
disease, amyotrophic lateral sclerosis, and multiple sclerosis. In addition, tumor necrosis
factor-α (TNF-α) secreted from activated microglia may elicit neurodegeneration through
caspase-dependent cascades and silencing cell survival signals. However, direct
neurotoxicity of TNF-α is relatively weak, because TNF-α also increases production of …
neuronal damage in neurodegenerative diseases, including Alzheimer disease, Parkinson
disease, amyotrophic lateral sclerosis, and multiple sclerosis. In addition, tumor necrosis
factor-α (TNF-α) secreted from activated microglia may elicit neurodegeneration through
caspase-dependent cascades and silencing cell survival signals. However, direct
neurotoxicity of TNF-α is relatively weak, because TNF-α also increases production of …