[PDF][PDF] Learning impairment in chronic epileptic rats following pilocarpine-induced status epilepticus.

JP Leite, EM Nakamura, T Lemos, J Masur… - TRIALS, 1990 - researchgate.net
JP Leite, EM Nakamura, T Lemos, J Masur, EA Cavalheiro
TRIALS, 1990researchgate.net
Male Wistar rats were subjected to pilocarpine-induced status epilepticus and allowed to
recover. After reaching the chronic state with spontaneous seizures they were tested in an 8-
arm radial maze. During learning trials, epileptic rats made significantly more errors than
controls. Even in the last trials epileptic rats did not improve their performance, indicating
severe learning disability. These results suggest that spontaneous seizures after pilocarpine-
induced status epilepticus are a useful model for studying the learning and memory …
Male Wistar rats were subjected to pilocarpine-induced status epilepticus and allowed to recover. After reaching the chronic state with spontaneous seizures they were tested in an 8-arm radial maze. During learning trials, epileptic rats made significantly more errors than controls. Even in the last trials epileptic rats did not improve their performance, indicating severe learning disability. These results suggest that spontaneous seizures after pilocarpine-induced status epilepticus are a useful model for studying the learning and memory impairment detected in some cases of symptomatic epilepsy.
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