Effects of interleukin-1β on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems
G Zhu, M Okada, S Yoshida, F Mori, S Ueno… - Epilepsy research, 2006 - Elsevier
Recent clinical and basic studies have demonstrated that hyperactivation of interleukin-1β
(IL-1β) plays important roles in generation of febrile and epileptic seizures. To clarify this
mechanism, the present study determined the effects of IL-1β on Ca2+-associated releases
of glutamate and GABA in mouse hippocampus. Both basal and K+-evoked GABA releases
were regulated by Ca2+ influx and Ca2+-induced Ca2+ releasing system (CICR). The K+-
evoked glutamate release was also regulated by Ca2+ influx and CICR, whereas basal …
(IL-1β) plays important roles in generation of febrile and epileptic seizures. To clarify this
mechanism, the present study determined the effects of IL-1β on Ca2+-associated releases
of glutamate and GABA in mouse hippocampus. Both basal and K+-evoked GABA releases
were regulated by Ca2+ influx and Ca2+-induced Ca2+ releasing system (CICR). The K+-
evoked glutamate release was also regulated by Ca2+ influx and CICR, whereas basal …