Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy
L Holtman, EA van Vliet, R Van Schaik, CM Queiroz… - Epilepsy research, 2009 - Elsevier
Inflammation is an important biological process that is activated after status epilepticus and
could be implicated in the development of epilepsy. Here we tested whether an anti-
inflammatory treatment with a selective cox-2 inhibitor (SC58236) could prevent the
development of epilepsy or modify seizure activity during the chronic epileptic phase.
SC58236 was orally administered (10mg/kg) during the latent period for 7 days, starting 4h
after electrically induced SE. Seizures were monitored using EEG/video monitoring until 35 …
could be implicated in the development of epilepsy. Here we tested whether an anti-
inflammatory treatment with a selective cox-2 inhibitor (SC58236) could prevent the
development of epilepsy or modify seizure activity during the chronic epileptic phase.
SC58236 was orally administered (10mg/kg) during the latent period for 7 days, starting 4h
after electrically induced SE. Seizures were monitored using EEG/video monitoring until 35 …