[HTML][HTML] Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection
Over the past three decades, improved immunosuppression has significantly reduced T cell–
mediated acute rejection rates, but long-term graft survival rates have seen only marginal
improvement. The cause of late graft loss has been under intense investigation, and chronic
antibody-mediated rejection (AMR) has been identified as one of the leading causes, thus
providing a strong rationale for basic science investigation into donor-specific B cells and
antibodies in transplantation and ways to mitigate their pathogenicity. In 2018, the American …
mediated acute rejection rates, but long-term graft survival rates have seen only marginal
improvement. The cause of late graft loss has been under intense investigation, and chronic
antibody-mediated rejection (AMR) has been identified as one of the leading causes, thus
providing a strong rationale for basic science investigation into donor-specific B cells and
antibodies in transplantation and ways to mitigate their pathogenicity. In 2018, the American …
